Patented Technology
The only skincare line with exclusive Methylene Blue patents
US 10,603,325
US 12,403,079 B2
the first hair growth product with methylene blue - patent pending
What is Methylene Blue?
Methylene Blue is a powerful antioxidant that penetrates skin cells at the mitochondrial level, the root cause of skin aging. Originally used as a medicine for over a century, Dr. Kan Cao's lab at the University of Maryland discovered its remarkable ability to reverse the signs of aging in human skin.
How Does It Work?
Methylene Blue neutralizes free radicals throughout the skin, from the mitochondria to the cell nucleus. It increases the lifespan of individual skin cells, doubles collagen and elastin production, improves connective tissue, and strengthens the skin's wound-healing ability. Results are typically visible within 3–4 weeks of use.
Why is it Better Than Retinol?
Our research shows Methylene Blue outperforms Retinol without the irritation often experienced by sensitive skin sufferers. Most surprisingly, the combination of Vitamin C and Methylene Blue has a true synergistic anti-aging effect:
Methylene Blue significantly reduced oxidative cell stress by scavenging ROS – while Retinol & Vitamin C had very little effect on skin health
Skin cells doubled w/ Methylene Blue while experiencing only small +/- variations with Retinol – more skin cells make more collagen & elastin!
The combination of Methylene Blue & Vitamin C boosted skin cell numbers as much as 300% (depending on age) when compared to retinol
Creating new skin cells
Bluelene®, made with our patented super-antioxidant Methylene Blue, helps to double your healthy skin cells better than Retinol – keeping your skin thriving for years to come.
Better skin in just two weeks
Methylene Blue treatment increases Collagen and Elastin production in skin cells in as little as two weeks, our hero patented ingredient is used in all of our skin care products.
Thickening the dermis layer
These cross-section images show three-dimensional human skin models made of living skin cells. The Untreated model skin (left panel) shows a thinner dermis layer compared with model skin treated with Methylene Blue (right panel) for 2 weeks, an increase in skin hydration and overall thickness.
Methylene Blue is a novel Coral Reef Safe Sunscreen
Data published by Nature Scientific Reports (May 2021) confirms Methylene Blue as a new full spectrum sunscreen, safe for humans and coral reefs:
Methylene Blue outperformed the most commonly used sunscreen active ingredient Oxybenzone and its derivatives
Methylene Blue protects skin against UVB radiation and repairs the photo-aging damages caused by UVA exposure
Coral reef exposed to Oxybenzone died within seven days, while coral prospered when treated with Methylene Blue
Peer-Reviewed & Published
Dr. Kan Cao's groundbreaking research on Methylene Blue was published in Nature Scientific Reports, one of the world's most respected peer-reviewed scientific journals. The research has been cited over 2,700 times by the global scientific community, making it one of the most impactful discoveries in anti-aging science.
📄 Published in Nature Scientific Reports
🏆 Invention of the Year Finalist — University of Maryland
🔬 Supported by NSF, NIH, TEDCO & University of Maryland
Ready to Experience the Science?
What Medical Experts are Saying
"The Night Plus+ has been a savior for my patients with extra dry sensitive skin, especially for those undergoing cancer treatments. My patients plagued by excessive dryness from chemo side effects are beyond happy they have a plus."
- Diane Madfes, MD, FAAD, Assistant Professor of Dermatology, Mount Sinai School of Medicine
"I have been using Bluelene skincare in practice for the past year and noticed amazing results especially when used post procedure. Bluelene skincare uses revolutionary technology with Methylene Blue – a powerful antioxidant – that is safe to use for all skin types, and all ages. Methylene Blue has been shown to have powerful healing abilities while also allowing regeneration of the tissue."
— Dr. Rahi, MD, Integrative Aesthetics, Beverly Hills & NYC